Genetics and Molecular Biology

Prof. Dr. med. Frank Stüber
Chefarzt und Direktor


Dr. rer. nat. Christoph Lippuner
Leiter biol.-wissenschaftl. Labor


PD Dr. med. Lutz Lehmann


Prof. Dr. med. Ulrike Stamer
Oberärztin II



The “Genetics and Molecular Biology Laboratory” is part of the Inselspital, University Hospital Bern and a member of the Department of Clinical Research, University Bern.
The focus of our group is on the genetic predisposition for perioperative morbidity and mortality. Our special interests are in the field of inflammation/immunology, cardio-vascular system, pharmacogenetics as well as pain medicine. Our projects embrace the influence of genomic variations from the molecular level to the clinical phenotype. In our lab we apply a broad spectrum of molecular and cell biological methods such as cell culture, fluorescence microscopy, flow cytometry, qPCR and genotyping. Our genotyping methods include single gene analysis as well as genome wide approaches. By using this methodological spectrum we link basic with clinical research.

List of selected projects

Brain Natriuric Peptide (BNP) (PDF)
Christoph Lippuner, Marianne Reinhardt,  Marcel Schiff, Sibylle Rohrbach, Rolf Lauber, Heinz Rieder, Frank Stüber, Malte Book

Copy Number Variations of the beta-defensin gene (PDF)
Xianghong Zhang, Christoph Lippuner, Malte Book, Frank Stüber

Signaling pathways involved in modulation of nociceptin and its receptor in human peripheral blood cells
Lan Zhang, Christoph Lippuner, Marcel Schiff, Frank Stüber, Ulrike Stamer

MicroRNAs Involved in Peripheral Blood in Acute or Chronic Pain
Lan Zhang, Christoph Lippuner, Marcel Schiff, Frank Stüber, Ulrike Stamer

Pilot study about „Neutrophil Extracellular Trap” formation during surgical porcedures. Is there a genetic predisposition? (PDF)
Marcel Schiff, Monika Stucki, Saskia Wahler, Malte Book, Frank Stüber, Christoph Lippuner

Influence of miRNAs on HLA-DR cell surface expression (PDF)
Matthias Staiger, Frank Stüber, Christoph Lippuner

Modulation of the gut inflammasome by different anaesthetic concepts (PDF)
Stefanie Wenger, Christoph Lippuner, Kathy McCoy (collaborator), Andrew MacPherson (collaborator), Frank Stüber

Tingting Wen, Marcel Schiff, Sibylle Rohrbach, Rolf Lauber, Frank Stüber, Christoph Lippuner, Ulrike Stamer

Collaboration partners

Dr. Volker Brinkmann
Max Planck Institute for Infection Biology, Berlin, Germany

Prof. Dr. med. Martin Fiedler, and Prof. Dr. phil. nat. Carlo Lagriadère
Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland

Prof. Dr. med. Andrew MacPherson and Prof. Dr. phil. Kathy McCoy Gastroenterology/Mucosal Immunology, Inselspital, Bern University Hospital and Department of Clinical Research, Bern, Switzerland

Dr. Matthias Platzer
Genome Analysis, Leibniz Institute for Age Research – Fritz Lipmann Institute, Jena, Germany