Clinical Research and Airway Management

Prof. Dr. med. Robert Greif, MME, FERC
Leitender Arzt
E-Mail

PubMed

The Airway Management group:

  • Evaluates the performance of new techniques and devices in difficult airway situations;
  • Organizes annually the basic and the advanced hands-on workshop, Airway Management Simulation and the Train the Airway Trainer course indicated by EAMS (European Airway Management Society);
  • Promotes multicenter studies through its affiliated society DARC: Difficult Airway Research Collaboration (www.darc-airway.com).

Ongoing randomized controlled trials and projects

  1. Rigid fiberoptics (Bonfils, SensaScope) in the simulated difficult airway scenario
  2. Supraglottic airway devices: Prospective observational study of pediatric supraglottic airway devices
  3. Supraglottic airway devices: Blind Intubation through the pediatric supraglottic airway devices AirQ vs. Ambu Aura-i
  4. Swiss Video Intubation Trial SWIVIT part 1 and part 2: Comparing 9 video-laryngoscopes in simulated difficult airway in a total of 1200 patients. A multicenter trial with the cooperation of HUG Geneva (PD Dr. G. Savoldelli) and CHUV Lausanne (PD Dr. P Schoettker)
  5. Difficult Environment Video-Intubation and Laryngoscopy (DEVIL) Evaluation of video-laryngoscopes under extreme environmental conditions on a Swiss Glacier
  6. Impact of the Train the Airway Trainer course on the Airway Trainers' teaching performance.
  7. Validity of Airway Assessment and rating tools

Collaborators

Lead: L. Theiler

Substitute

M. Kleine-Brüggeney; S. Seiler; F. Stucki, S. Signer, Y. Berger, A. Gottfried, F. Sermann, A. Nicolet 

Other collaborators

S. Nabecker, University Hospital, Bern
M. Kotarlic, University of Wittgen, Germany
P. Schoettker, CHUV Lausanne
G. Salvoldelli, HUG Lausanne
K. Arheart, University of Miami, FL, USA

Pharmacokinetics and -dynamics of Tetrahydrocannabinol (THC)

PD Dr. med. Lorenz Theiler, CAS
Leitender Arzt
E-Mail

PubMed

The THC pharmacology group:

  • Evaluates the efficacy of intravenously applied THC on postoperative nausea and vomiting
  • Analyzes the degradation of THC in relation to CYP2C9 single nucleotide polymorphisms
  • Works in collaboration with scientists from Lausanne CHUV, Munich Germany, Ft. Lauderdale, USA and Forensic Departments in Bern and Munich to optimize ressources and gather knowledge

Ongoing randomized controlled trials and projects

  1. What is the influence of THC on PONV?
  2. What model predicts the degradation of THC in relation to CYP2C9 and other predictors? Is there a relevant difference to earlier models?
  3. What is the relevance of those findings to forensic departments and researchers?
  4. Changes of pupillary dynamics in relation to THC
  5. Chemical stability of THC
  6. Influence of THC application on corticosteroids and endocannabinoids
  7. Influence of THC application on human adrenal glands

Collaborators

R. Greif, M. Kleine-Brüggeney, S. Suker and S. Mustafa

Other collaborators

W. Bernhard, Inst. Forensic Medicine, University of Bern
E. Gouzman, Dépt. des Laboratoires, Centre Hospitalier Universitaire Vaudois
H. Sachs, Forensic and Toxicologic Center, Munich
G. Schelling, University of Munich
W. R. Wolowich, NOVA Southeastern University, Ft. Lauderdale, FL, USA