Respiratory System/Pulmonary Gas Exchange
Current work of the research group focuses on pulmonary gas exchange. Key aspects are quantification of ventilation-perfusion-distribution in different compartments of the lung, an in-vitro lung model for validation and improvement of the methodology, and further development of the technology and devices in use.
Time-resolved VA/Q Distribution Analysis by Multiple Inert Gas Elimination Technique (MIGET) Based on Micropore Membrane Inlet Mass Spectrometry (MMIMS)
Aim of the project is to demonstrate the feasibility of MMIMS-MIGET based monitoring of rapid changes in pulmonary gas exchange during respiratory failure or acute lung injury. Availability of such information offers the opportunity to adjust therapy of critically ill patients close to real time. MIGET is a proven technique, but conventional gas chromatography (GC) MIGET requires several hours to obtain raw data whilst MMIMS can deliver similar results within fifteen minutes.
Development of an in-vitro lung model (IVLM) for MMIMS-MIGET test analysis
A five compartment in-vitro gas exchange model was designed using membrane oxygenators as gas exchangers. After determination of retention and elimination characteristics of the material in use, MMIMS-MIGET was validated against known ventilation-perfusion relationships. Current work focuses on automation of gas and perfusate flow regulation to improve reproducibility and shorten duration of experiments.
Consiglio J, Mayr B
Department of Cardiovascular Surgery, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland
Duenges B, Bodenstein M, Wang H
Department of Anaesthesiology, Johannes Gutenberg-University, Mainz, Germany
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University, Mainz, Germany
Department of Medical Sciences, Section of Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden
Böhme S, Klein K, Markstaller K
Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria
Oscillogy LLC, Folsom PA, USA
- Bangerter-Stiftung für medizinische Forschung, Basel, Switzerland
- Stiftung Forschung in Anästhesiologie und Intensivmedizin Bern, Switzerland
- Swiss National Foundation SNF POIB-117065/1