Respiratory System/Pulmonary Gas Exchange

Head of projects:
PD Dr. Andreas Vogt
E-Mail

 

Current work of the research group focuses on pulmonary gas exchange. Key aspects are quantification of ventilation-perfusion-distribution in different compartments of the lung, an in-vitro lung model for validation and improvement of the methodology, and further development of the technology and devices in use.

 

Projects

Time-resolved VA/Q Distribution Analysis by Multiple Inert Gas Elimination Technique (MIGET) Based on Micropore Membrane Inlet Mass Spectrometry (MMIMS)

Aim of the project is to demonstrate the feasibility of MMIMS-MIGET based monitoring of rapid changes in pulmonary gas exchange during respiratory failure or acute lung injury. Availability of such information offers the opportunity to adjust therapy of critically ill patients close to real time. MIGET is a proven technique, but conventional gas chromatography (GC) MIGET requires several hours to obtain raw data whilst MMIMS can deliver similar results within fifteen minutes.

Development of an in-vitro lung model (IVLM) for MMIMS-MIGET test analysis

A five compartment in-vitro gas exchange model was designed using membrane oxygenators as gas exchangers. After determination of retention and elimination characteristics of the material in use, MMIMS-MIGET was validated against known ventilation-perfusion relationships. Current work focuses on automation of gas and perfusate flow regulation to improve reproducibility and shorten duration of experiments.

Collaborations

Consiglio J, Mayr B
Department of Cardiovascular Surgery, Swiss Cardiovascular Center, University Hospital, Bern, Switzerland

Duenges B, Bodenstein M, Wang H
Department of Anaesthesiology, Johannes Gutenberg-University, Mainz, Germany

Röhrig B
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University, Mainz, Germany

Hedenstierna G
Department of Medical Sciences, Section of Clinical Physiology, Uppsala University Hospital, Uppsala, Sweden

Böhme S, Klein K, Markstaller K
Department of Anaesthesia, General Intensive Care and Pain Management, Medical University of Vienna, Vienna, Austria

Industrial Cooperations

Oscillogy LLC, Folsom PA, USA

Financial Support

- Bangerter-Stiftung für medizinische Forschung, Basel, Switzerland
- Stiftung Forschung in Anästhesiologie und Intensivmedizin Bern, Switzerland
- Swiss National Foundation SNF POIB-117065/1

Publications

Papers
Häller, Lukas
Comparison of various venous blood withdrawals for multiple inert gas elimination technique (MIGET) by micropore membrane inlet mass spectrometry in a porcine lung injury model.
Thesis, Master of Medicine, Medical Faculty of the University of Bern, June 27, 2014

Posters & Presentations
Riggenbach C, Rothen H-U, Eberle B, Vogt A
Validation of Multiple Inert Gas Elimination Technique by Micropore Membrane Inlet Mass Spectrometry in an In-Vitro Lung Model of Lung Compartments With Low-to-Normal Ventilation-Perfusion Ratios
P6, Annual meeting Swiss Society of Anesthesiology and Resuscitation,
SGAR/SSAR Lausanne, November 7–9, 2013
Swiss Med Wkly 2013;143(Suppl 201):10 S

Varadarajan B., Riggenbach C., Rothen H.U., Eberle B., Vogt A.
Validation of MMIMS-MIGET (multiple inert gas elimination technique by micropore membrane inlet mass spectrometry) in an in vitro lung model of lung compartments with low-to-normal ventilation-perfusion ratios (VA/Q): 5AP1-10.
2013 Euroanaesthesia Meeting of the European Society of Anaesthesiology in Barcelona
European Journal of Anaesthesiology (EJA) 2013; 30 (Suppl. 51): 83-83

Varadarajan B, Gerber D, Vandenberghe S, Rothen HU, Eberle B, Vogt A.
Near-real time pulmonary shunt and deadspace measurement with multiple inert gas
elimination technique (MIGET) by micropore membrane inlet mass spectrometry (MMIMS) in porcine lung injury models: 5AP1-9.
2013 Euroanaesthesia Meeting of the European Society of Anaesthesiology in Barcelona
European Journal of Anaesthesiology (EJA) 2013; 30 (Suppl. 51): 82-83

Riedel T, Gerber D, Rothen H-U, Eberle B, Vogt A.
Electrical impedance tomography-based assessment of ventilation-perfusion relationships in a porcine lung lavage model: a feasibility study.
Free communication F24, Joint Anniversary Meeting SGAR/SSAR, SGI/SSMI, SIGA/FSIA, SGNOR/SSMUS, Basel/CH, 15.-17.11.2012
Swiss Medical Forum 2012;12(Suppl. 59): 13 S

Varadarajan B, Consiglio J, Mayr B, Eberle B, Vogt A.
In vitro lung model to assess gas exchange by multiple inert gas elimination technique (MIGET) using micropore membrane inlet mass spectrometry (MMIMS): 5AP1?11. 2012
Euroanaesthesia Meeting of the European Society of Anaesthesiology, Paris, France
European Journal of Anaesthesiology (EJA) 2012, 29 (Suppl. 50):82-83.

Varadarajan B, Gerber D, Eberle B, Vandenberghe S, Vogt A.
Near-real time pulmonary shunt measurement with Multiple Inert Gas Elimination Technique (MIGET) by Micropore Membrane Inlet Mass Spectrometry (MMIMS) in a porcine lavage lung model. 3AP2?9.
2012 Euroanaesthesia Meeting of the European Society of Anaesthesiology, Paris, France
European Journal of Anaesthesiology (EJA) 2012, 29 (Suppl. 50):42.